P29-5 Observation on the clinical efficacy of plant-extracted compound for brain metastatic tumor after failure with multi-line therapy

8%-10% of patients with advanced cancer have intracranial metastases. At present, the treatments mainly include surgery, SBRT, whole brain radiotherapy, chemotherapy et al, but once cannot tolerate those methods, palliative care shown good effects. Plant-extracted drugs, which are important part treatment, play roles in inhibiting tumor progress, reducing adverse reactions radio-chemotherapy, and improving quality life. 54 patients, who diagnosed metastasis were failure multi-line therapy, enrolled. The plant-extracts grugs (Xianhe Baijiang Shenhuang capsules) used, contain Agrimonia pilosa Ledeb, Patrinia scabiosaefolia, ginseng Astragalus al. Intracranial site, clinical symptoms, median survival, KPS score, side-effects observed. percentage supratentorial metastases, subtentorial both metastases 88.88% (48 cases), 5.56% (3 respectively. Since diagnosis at first time, dizziness, headache, decreased muscle strength observed 25 (46.30%), 29 (53.70%) symptomless. After score was 43.70±27.77 compared to 39.63±23.95 (p=0.028), improved up 51.85%. Meanwhile, according CTCAE3.0, no level II or above drug-related digestive hematology Last, survival (mOS) reached 4.5 months since patient received plant-extracted longest time 102 months. In summary, large proportion metastatic tumors occurred without led miss early treatment opportunities. Also, suffered low could improve life prolong time.